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Latest from Actorius

Explore the latest updates, research perspectives, announcements, and stories shaping our work.

Preoperative CTC levels predict prognosis and survival in oral squamous cell carcinoma.
1 Jul 2022

Manuscript: Circulating tumor cells as a predictor for poor prognostic factors and overall survival in treatment nay¨ve oral squamous cell carcinoma patients

Preoperative circulating tumor cell levels strongly correlate with metastasis, disease severity, and reduced survival in oral squamous cell carcinoma patients.

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ASCO 2022 | Actorius Innovations and Research
7 Jun 2022

ASCO 2022: CTCs as a biomarker for monitoring: Disease progression, treatment response, and minimal residual disease.

Study of 127 patients shows CTCs are a dynamic biomarker for monitoring disease progression and therapy response in advanced epithelial cancers.

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ASCO. 2022 | Actorius Innovations and Research
7 Jun 2022

ASCO 2022: Machine learning (ML)–enabled, circulating tumor cell–based classification of patients for non-prerequisite adjuvant therapy.

An XGBoost ML model using CTCs and clinical data achieved 84% accuracy in predicting the need for adjuvant therapy in 380 HNSCC patients.

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ASCO 2022 | Actorius Innovations and Research
7 Jun 2022

ASCO 2022: Extracorporeal microchannel device to capture and eliminate circulating tumor cells from
cancer patient’s blood.

A 3D-printed G-EpCAM device successfully captured over 85% of CTCs with minimal hemolysis, offering a new way to stem metastatic progression.

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ASCO 2022 | Actorius Innovations and Research
7 Jun 2022

ASCO 2022: A feasibility study of EMF (erlotinib+methotrexate+5-fluorouracil) regimen in recurrent HNSCC and role of CTCs in assessment of outcomes.

A phase II trial shows EMF triplet therapy is a safe, effective option for HNSCC, with CTCs serving as a promising biomarker for therapy response.

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ACO 2022 | Actorius Innovations and Research
7 Jun 2022

ASCO 2022: Correlation of circulating tumor cells as a positive interventional biomarker in cancer patients

Ayurveda therapy significantly reduced CTC counts and improved quality of life in a study of 72 patients across 17 cancer types.

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Bioinspired Materials for Wearable Devices and Point-of-Care Testing of Cancer
27 Apr 2022

Manuscript: Bioinspired Materials for Wearable Devices and Point-of-Care Testing of Cancer

Raj Shankar Hazra, Md Rakib Hasan Khan, Narendra Kale, Tabassum Tanha, Jayant Khandare, Sabha Ganai, and Mohiuddin Quadir*

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Antibody-coated cotton substrate for CTC enumeration and chemotherapy response.
18 Feb 2022

Manuscript: Antibody mediated cotton-archetypal substrate for enumeration of circulating tumor cells and chemotherapy outcome in 3D tumors

Cotton microfluidic substrate enables efficient CTC isolation, 3D tumor growth, and drug response testing for improved cancer diagnostics and therapy research.

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ESMO 2021 | Actorius Innovations and Research
9 Oct 2021

ESMO 2021: Validation of Cytokeratin (CK18) Protein Expression in Epithelial Cell lines and in Circulating Tumor Cells (CTCs)

Study shows significant CK18 expression variance across different cancer cell lines and CTCs, highlighting the need for regulated enumeration tools.

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ASCO 2021 | Actorius Innovations and Research
8 Jun 2021

ASCO 2021: CTCs demonstrate a positive biomarker in head and neck squamous cell carcinoma (HNSCC) in tobacco consuming population of Bangladesh.

A study in Bangladesh found CTCs in 64% of HNSCC patients with chronic tobacco history, suggesting CTCs as a screening tool for early cancer detection.

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Chemo-specific designs for the enumeration of CTCs: advances in liquid biopsy
18 Dec 2020

Manuscript: Chemo-specific designs for the enumeration of circulating tumor cells: advances in liquid biopsy

Review on chemo-specific nano/micro substrates for efficient CTC isolation, enabling liquid biopsy, metastasis detection, and real-time cancer monitoring.

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Cellulose-based transferrin nanocages for CTC enumeration in head & neck cancer.
10 Oct 2020

Manuscript: Cellulose Mediated Transferrin Nanocages for Enumeration of Circulating Tumor Cells for Head
and Neck Cancer

Magnetic transferrin-functionalized cellulose nanocages capture circulating tumor cells from blood, enabling liquid biopsy for early metastasis detection in head and neck cancer.

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Actorius Innovations and Research
15 Jul 2020

ASCO 2020: Device for the enumeration and continuous removal of circulating tumor cells in improving
overall survival of epithelial cancer patients

The POP blood fluidic device safely removes CTCs with up to 100% efficiency, offering a new therapeutic path to reduce metastasis and improve survival.

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Times of India | Actorius Innovations and Research
23 Apr 2020

Times of India | Liquid biopsy may replace invasive procedure to detect cancer: Experts

Liquid biopsy may replace invasive procedure to detect cancer: Experts

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ASCO 2020 | Actorius Innovations and Research
15 Mar 2020

ASCO 2020: Correlation of CTCs with disease progression in Indian oral cancer patients.

In 230 OSCC patients, CTC counts correlated with cancer stage and aggressive features, proving CTCs are a reliable marker for disease stratification.

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Economic Times - Business Standard | Actorius Innovations and Research
24 Aug 2019

Pune scientists discover tech, first in India, to detect early spread of cancer.

The new "OncoDiscover" technology discovered by a team led by Dr Jayant Khandare not only detects the early spread of cancer but doctors say it can also speed up the cancer detection process…

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Startup Mantra | Actorius Innovations and Research
24 Aug 2019

Startup Mantra: Making cancer detection more accessible and affordable to people

Launching ‘OncoDiscover Liquid Biopsy Test’, a minimally invasive test which can be performed multiple times requiring 1.5ml blood volume...

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ASCO 2019 | Actorius Innovations and Research
4 Jun 2019

ASCO 2019: Correlation of CTCs with disease progression in Indian oral cancer patients

"OncoDiscover" is a fast, highly sensitive, and affordable (~$120) CTC nanosystem validated in 100 HNC patients to meet global medical needs.

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Magnetic nanogels enable optimized capture of circulating tumor cells from blood.
11 Feb 2018

Manuscript: Optimizing Circulating Tumor Cells’ Capture Efficiency of Magnetic Nanogels by Transferrin Decoration

Magnetic nanogels with optimized PEG–transferrin linkers achieve over 80% efficiency in selectively capturing circulating tumor cells from blood.

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Micropatterned surfaces enable selective cancer cell capture and real-time monitoring.
17 Jan 2018

Manuscript: Selective Cell Isolation by Transferrin Functionalized Silane– Carbon Soot Mediated Superhydrophobic Micropatterns

Transferrin-functionalized wettability micropatterns enable selective cancer cell capture and real-time monitoring for diagnostics and recurrence detection.

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